Lead Optimization is a critical phase in the drug discovery and development process. During this stage promising lead compounds typically identified during the hit-to-lead phase undergo extensive refinement and optimization.
At o2h discovery, the lead optimization services are chosen based on the specific characteristics and needs of each drug discovery project. These services encompass a range of activities aimed at refining lead compounds including structural modifications, pharmacological profiling to enhance efficacy, safety and pharmacokinetic properties, toxicity assessment and in dissecting compound’s mechanism of action. The ultimate aim is to select a single lead compound or a small group of lead candidates with the highest potential for success as a new therapeutic agent.
To know more about our integrated drug discovery services offering or to request our brochure, please reach out to us at discovery@o2h.com.