our biology capabilities
o2h discovery has expanded its biology capabilities across different therapeutic areas in Cambridge, UK and Ahmedabad, India. We have built a team of highly qualified scientists Ph.Ds. with >10 years of experience and Masters with extensive industrial experience.
Creating an integrated approach to drug discovery by expanding biology capabilities alongside chemistry and ADME in Ahmedabad, India. We can support you in accelerating your design-make-test-analyse cycles providing a robust iterative screening platform to advance your discovery program.
o2h discovery has invested in state-of-the-art technology platforms for your preclinical drug discovery programs through lead optimization to candidate selection & further development to IND filing.
Our experienced cell biologists in Cambridge, UK can develop customizable assays for diverse target classes. Compounds can be profiled for their potency to efficacy translation in cellular assays for functional characterization and MOA.
integrated drug discovery & target biology
o2h offers a spectrum of label and label-free, medium to low throughput screening platforms for hit identification. Whether it’s Fragment-based screening or your custom libraries/compounds, we help you unearth promising leads. Hits from primary screens undergo rigorous validation in orthogonal assay platforms. This ensures compound re-confirmation, rank ordering, and prioritization.
We have a proven track record of working with “me too” and “undruggable” class of targets. This coupled with a good understanding of potency to efficacy translation, we can provide an integrated suite of high-quality biophysical, biochemical & cellular-assay platforms.
While we have a strong foundation in target discovery and chemical biology, with particular expertise in oncology and metabolic syndrome, our capabilities extend beyond these boundaries.
state-of-the-art technology platforms
- Biacore T200 Surface Plasmon Resonance (SPR) – label-free technology for fragment based/small molecule screening
- CLARIOstar Plus & PHERAstar – Modular, upgradable platforms for a broad range of Fluorescence & Luminescence- based screens e.g. FRET, TR-FRET, FP, BRET, AlphaScreen etc.
- Robotics: Integra Assist Plus and ViaFlow, semi-automated platforms for compound dilutions and increased screening throughput
- Hamilton Star with 96 well multi-probe head and independent 8 channel pipetting head
- Opentrons OT2 with 8-channel P20 and 8-channel P300 pipettors
- Bio-Rad CFX96: SYPRO Orange fluorescent dye-based thermal stability for compound-target engagement
- Thermo CX7 LED: High-content imaging platform
- FLIPR Penta for ion channels and GPCR biology
- CytoFLEX S for cell cycle and population analysis
To know more about our biology services offering or to request our brochure, please reach out to us at discovery@o2h.com.
