PROTACs
(PROteolysis TArgeting Chimeras)PROTACs are a specific type of molecule or compound designed for targeted protein degradation (TPD). TPD involves employing heterobifunctional small molecules known as “Degraders,” like PROTAC Degraders, or utilising PROTAC services to effectively reduce the levels of specific target proteins within cells. PROTACs are heterobifunctional small molecules consisting of a target binding handle bridged via a chemical linker to an E3 ligase handle which hijacks the endogenous ubiquitin machinery to target proteins, resulting in subsequent ubiquitination and degradation of your target of interest.
PROTACs provide significant therapeutic potential with possible prolonged pharmacodynamics, improved potency, and ability to target proteins previously thought of as “undruggable”.
o2h discovery offeres intigrated PROTAC synthesis services as well as a bespoke and customisable “off-the-shelf” PROTAC toolbox to jump-start your targeted protein degradation program, along with our strong expertise in medicinal and synthetic chemistry.
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