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Peptide Synthesis

o2h discovery has the expertise and capabilities to support custom peptide synthesis, purification, phys-chem properties and biology evaluation of Peptide molecules…

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About o2h discovery:

Founded in 2005, o2h discovery has a multi-modality integrated drug discovery platform, operating from Cambridge, UK, and Ahmedabad, India. We have the in-house capability to execute hit-lead-optimization programs leading into patent and IND filing with expertise in discovery chemistry, biology, pharmacology, and the ongoing project management of pre-clinical development.

We have experienced scientists who can deliver a comprehensive range of custom peptide synthesis services, from small quantities of a few milligrams to larger amounts reaching gram scale. Our capabilities extend beyond standard peptide synthesis to include specialised peptide modification services, allowing for the customisation and optimisation of peptides to support a diverse range of drug discovery programmes.

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Our Capabilities:

We have solid and solution phase synthesis expertise enabling us to create peptide mimics and complex peptides at the desired scales

Our experienced team of scientists have the capability to synthesise up to 50-mer linear peptides and develop cysteine-rich disulphide-bridged peptides for enhanced stability

We can produce peptide libraries for quick screening

Our fully automated Parallel Peptide Synthesizer Syro I can handle the solid-phase synthesis of up to 24 peptides simultaneously

We have a state-of-the-art analytical facility and a highly skilled team specialising in purification and characterisation of complex peptides

Want to learn more about our custom peptide chemistry services and how we can support your research and development goals?

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Equipment Overview

We have a fully automated Parallel Peptide Synthesizer Syro I equipped to handle a range of peptide synthesis. Some of the key features Syro I include:

Conventional Heating option (max 96 deg C)

Scale range 0.001 to 0.6 mmol (1 to 600 umol)

Max no of peptides 96

Reactor vial size 2, 5, 10 and 20 mL

In-situ and pre-activation both

Amino acid vessel standard 40 x 50 mL

Reagent Bottles 5 (2 x 500 mL; 3 x 200 mL)

External Bottle 1

Vortex mixing (speed control knob)

Inert gas blanket option

2 digital Syringe pumps for liquid handling

Fully Automated with one robotic arm

Separate cleavage workstation

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Peptide Modification Services

In addition to synthesis, our experienced team of chemists also excel in performing a wide range of peptide modifications, including but not limited to the following:

Branched Peptides

Succinylated Peptide

Stapled Peptides

Acetylated Peptides

Cyclic Peptides

PEGylated Peptides

Citrullinated Peptides

Phosphorylated Peptides

Amidated Peptides

Biotinylated Peptides

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Analytical Suite Overview

We have an experienced team of dedicated analytical scientists and labs equipped with the latest instrument to manage and achieve high ‘speed’ delivery of peptide projects.

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Meet our team

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Sunil Shah

CEO - o2h Ventures and Co-Founder - o2h group

Sunil's Biography

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Sunil Shah

CEO - o2h Ventures and Co-Founder - o2h group

A serial entrepreneur having begun a career in the Life Sciences team at PA Consulting group followed by co-founding two companies in the information technology and life sciences sector. The second of these companies, Oxygen Healthcare Ltd was acquired by Piramal Enterprises Ltd (BSE: PEL). Sunil co-founded o2h ventures which involves discovery services / collaborations, seeding drug discovery, academic in-licensing and biotechnology incubation. Sunil has a degree in Biochemistry and an MBA from Cambridge University.


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Prashant Shah

CEO - o2h discovery and Co-Founder - o2h group

Prashant's Biography

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Prashant Shah

CEO - o2h discovery and Co-Founder - o2h group

Prashant is a serial entrepreneur in life sciences and tech in which one of those companies was acquired by a public company. He is currently active in seed investing (a portfolio of ~50 companies), product/IP development, services, and building lab/office infrastructure. The early career was with the Strategy group at Accenture. He has a BEng, an MSc, in which he worked on the Human Genome Program at the Sanger Centre, and an MPhil in Management from the Judge Institute. Prashant is also a General Partner in the o2h SEIS/EIS Human Health Funds.


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Nilesh Dagia

Chief Special Projects Officer

Nilesh's Biography

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Nilesh Dagia

Chief Special Projects Officer

Nilesh leads the global operations of o2h group covering a wide range of innovation led investment, life-science and technology businesses. He is also overseeing the development and execution of the new o2h discovery Shirish Research Centre in Ahmedabad, India. Prior to joining o2h group, Nilesh worked with Piramal Group in various capacities including as an Alliance Manager for a risk-share oncology-based collaboration with a US Big Pharma and has also worked as the Head of Biology in Piramal Discovery solutions. Nilesh obtained his Ph.D. from Ohio University and completed a post-doc in Immunology, Stem Cells and Regenerative Medicine at Harvard Medical School. He is the author and inventor of >30 life science patents and publications. He received the Young Scientist of India award from OPPI in 2010.


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Andy Morley

Chief Scientific Officer

Andy's Biography

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Andy Morley

Chief Scientific Officer

Andy is a highly experienced and accomplished Medicinal Chemist with over 25 years of experience in major pharmaceutical companies such as Sanofi-Aventis and AstraZeneca. He has extensive experience across all phases of drug discovery and has played a key role in the development of five candidates that have reached clinical trials. Andy is a prolific author and inventor, with over 55 publications and patents to his name. Since 2013, he has been working full-time with o2h Limited, where he leads the scientific evaluation of investment opportunities and provides scientific support. He has also served as CSO for two early-stage collaborations within the o2h Ventures portfolio, demonstrating his ability to successfully guide drug discovery projects from concept to clinical development.


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David Davies

Head of Medicinal Chemistry

David's Biography

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David Davies

Head of Medicinal Chemistry

David Davies has 25 years of experience in medicinal chemistry within the pharmaceutical industry with a focus on the antibacterial area (clavulanates, penicillinates, pseudomonates and bacterial topoisomerase inhibitors). He previously worked at GSK and currently holds a part-time academic position at University College London (UCL). He served as the Head of Medicinal Chemistry at Antabio for nearly a decade, specialising in antibacterial research, and has extensive experience managing chemistry projects in multiple countries including France, UK, India and China. He is the inventor of 40 patents and has authored 37 publications.


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Hemal Soni

Vice President - Chemistry

Hemal's Biography

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Hemal Soni

Vice President - Chemistry

Hemal has comprehensive experience in leading & guiding multi-FTE synthetic chemistry research and development collaborations which are in support of the fast-paced drug discovery programs. At o2h discovery, he oversees the progress and troubleshooting of all the ongoing projects and helps with evaluation as well as kick start of new programs. Hemal obtained his Ph.D. in organic chemistry from Kadi Sarva University, Gujarat. He has >17 years of industrial experience. Prior to joining o2h discovery, Hemal worked with Piramal Discovery Solutions (PDS) for 4 years during which he led the largest project covering 42 FTEs for a UK-based collaborator. He has worked with clients all around the world including UK, USA, Japan, Australia, Singapore and more.


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Claudio Dagostin

Vice President - Business Development (UK & Europe)

Claudio's Biography

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Claudio Dagostin

Vice President - Business Development (UK & Europe)

Claudio obtained his PhD in Chemistry (Mechanisms of Organic Reactions) from the University of Rome in 2000. He went for a post-doc at Imperial College London where he worked on Alzheimer’s disease chemical probes. In 2004, he started working in several companies in the Cambridge biotech cluster where he deepened his knowledge in Medicinal Chemistry and in Fragment Based Drug Design. In 2012, he went back to academia at Cambridge University where he investigated challenging drug targets such as protein-protein interactions. He also co-founded the Entrepreneurial Postdocs of Cambridge (EPOC) society in 2015 to support postdocs in their pursuit of entrepreneurial careers. In 2017, joined Capital Cell with a role in Business Development, then Abzena in Cambridge and finally o2h in January 2021.


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Dr. Catherine Stace

Vice President - Business Development (East Coast USA) & Strategic Relationship

Dr.'s Biography

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Dr. Catherine Stace

Vice President - Business Development (East Coast USA) & Strategic Relationship

Dr. Catherine holds over 18 years of post-doctoral experience in therapeutic discovery, with strategic roles in biotechnology, consultancy, and CRO organizations. She has contributed to small molecule therapeutics, peptides, health tech, and engineering. She started her career at Isogenica and Bicycle Therapeutics, establishing therapeutic platforms and discovery programs. She has also consulted for various biotech and health tech start-ups to develop platform technologies at the intersection of biology and engineering. Before joining o2h, she was EVP of Business Development at Domainex, collaborating with companies in the UK, USA, and Europe. She has completed an MSc in Biochemistry from Nottingham, a PhD in Cell Biology from Cambridge, and an MBA from the Open University.


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Gayathri Sadasivam

Vice President - Biology

Gayathri's Biography

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Gayathri Sadasivam

Vice President - Biology

Gayathri leads the biology capabilities in Ahmedabad, India and Cambridge, UK. She also significantly contributes to the business development with the o2h customers world-wide, understanding the market requirements, contributing to technology transfer and investment evaluations. Prior to this, she has worked for >15 years in different therapeutic areas in both industry and academia. She has led multiple programs in drug discovery projects through lead optimization to candidate selection and further development to late stage clinical trials. She has worked in a multi-disciplinary environment, leading chemical biology efforts creating chemical tools that modulate novel class of “undruggable” targets. Gayathri has a Ph.D. in Neuroscience from the Brain Research Institute, Zurich, Switzerland.


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Tejas Upadhyay

Vice President - Business Development (USA)

Tejas's Biography

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Tejas Upadhyay

Vice President - Business Development (USA)

Tejas holds a master’s degree from Gujarat University, earned his PhD in India, and gained valuable post-doctoral experience at the University of Glasgow in the United Kingdom. His professional journey commenced at Alembic, and he has since contributed his expertise to several contract research organisations, including Evotec, o2h, and Piramal. Currently, he oversees all projects in the USA region. With a background in chemistry, he boasts over two decades of experience in the field of preclinical drug discovery.


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Dharmesh Bhatt

Head - Business Development (India)

Dharmesh's Biography

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Dharmesh Bhatt

Head - Business Development (India)

Dharmesh obtained his Master’s degree in Chemistry from M.K University and has done MBA in industrial Management from National Institute of Management. He has about 27 years of industrial experience during which he has served many MNCs like Zydus Cadila, Piramal, Dishman Pharma, Daicel etc. He has immense expertise in the purification, isolation & characterization of heterocyclic, macrocyclic, natural products, etc. Dharmesh was also in role of Sales & BD for analytical services, pharma impurity standard, separation services & column business for domestic market.


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Simon Stockwell

Senior Scientist II

Simon's Biography

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Simon Stockwell

Senior Scientist II

Simon is a senior cell biologist with over 16 years’ postdoctoral experience working in academic research laboratories. Prior to joining o2h discovery, he contributed to various small molecule drug discovery projects with experience in target validation, screening and hit-to-lead stages. Specializing in high-content image analysis, Simon has supervised screens and developed novel assays for a variety of therapeutic targets in oncology. His postdoctoral career was spent at The Institute of Cancer Research and UCL Institute in London, then more recently with the MRC Cancer Unit in Cambridge.


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